Até hoje a causa de sua morte é amplamente debatida. Alexandre morreu de alguma doença transmitida por inseto, de alguma infecção ou teria sido envenenado?
No post Death of Alexander the Great, em About.com: Ancient / Classical History, escrito por N. S. Gill, se lê:
Today  is the anniversary of the death of Alexander the Great in 323 B.C. What killed him is still open to debate. An article claiming Alexander the Great could have died of West Nile Virus looks at the type of evidence most historians would overlook, including the fact that there is a swamp near where Alexander died that could have been the breeding grounds for insect-borne diseases. In The Death of Alexander the Great, Paul Doherty looks very carefully at the historical evidence and then concludes that Alexander died from arsenic poisoning.
Como dito acima, há controvérsias quanto à data da morte de Alexandre. Os dias 10, 11 e 13 são defendidos por diferentes especialistas.
Alexander died on 11 June 323 BCE, in the late afternoon; this can be deduced from the Astronomical diaries, a Babylonian source. Several scholars have argued for 13 June and 10 June, but the first of these dates is based on an inaccurate Greek source that uses a confused Egyptian calendar, and the second is based on inaccurate reading of the Astronomical diary.
Leia mais sobre Alexandre em As Conquistas de Alexandre Magno (356-323 a. C.) e em Quem é Alexandre Magno?
Sobre o filme Alexandre, de Oliver Stone, acho que todos ouviram falar, não?